Table 1.

Chronic Rhinosinusitis Disease State Classification

CRS Disease State	Definition
Chronic rhinosinusitis (CRS)	• At least two cardinal symptoms (obstruction, drainage, smell loss, facial pain/pressure) • Minimum of 3 months duration • Objective evidence of sinus inflammation via endoscopy and/or CT imaging
CRS exacerbation	Met definition for CRS in past AND: • Preceded by defined duration of mild/moderate symptoms for 1+ month • At least a single cardinal symptom worsening within the past 7 days
Recalcitrant CRS	Met definition for CRS in the past AND: • Two or more sinus surgeries; OR • Oral corticosteroid treatment more than twice per year for CRS indication; OR • Antibiotics more than three per year for CRS indication; OR • Polyps recurred after sinus surgery
Remitted CRS	Met definition for CRS in the past AND: • No moderate or severe symptoms that persisted for at least 3 months in prior year; AND • No antibiotics, oral corticosteroids, or surgery for CRS in past year