Ablation of CD47 mitigates splenomegaly and antibody deposition in CD47−/−–Faslpr mice. A–B) Photographs and weight comparison (n=7) of spleens from WT, CD47−/−, Faslpr and CD47−/−–Faslpr mice at 8 months. C) Splenocyte numbers in WT, Faslpr and CD47−/−–Faslpr mice (n=7). D–F) Kinetics of total serum IgG level (D), serum ANA level (E) and serum anti-dsDNA antibody level (F) in WT, CD47−/−, Faslpr and CD47−/−–Faslpr mice (n=7).