Table 1.
Effect of hemorrhagic shock and IKK16 treatment on white blood cells.a
| Sham + Vehicle | Sham + IKK16 | HS + Vehicle | HS + IKK16 | |
|---|---|---|---|---|
| WBC (k/μL) | 5.34 ± 0.11 | 5.10 ± 1.38 | 7.34 ± 1.55 | 8.17 ± 1.94 |
| Neutrophils (k/μL) | 2.11 ± 1.02 | 1.86 ± 0.66 | 1.19 ± 1.26 | 1.95 ± 2.32 |
| Lymphocytes (k/μL) | 2.83 ± 1.02 | 3.03 ± 1.20 | 5.58 ± 2.10*b | 5.6 ± 1.45* |
| Monocytes (k/μL) | 0.33 ± 0.19 | 0.28 ± 0.03 | 0.47 ± 0.21 | 0.56 ± 0.17 |
| Eosinophils (k/μL) | 0.06 ± 0.10 | 0.02 ± 0.02 | 0.04 ± 0.06 | 0.03 ± 0.02 |
| Basophils (k/μL) | 0.00 ± 0.00 | 0.01 ± 0.01 | 0.06 ± 0.06 | 0.03 ± 0.04 |
a
Rats were subjected to HS and received IKK16 (1 mg/kg; i.v.) or vehicle (10% DMSO) at resuscitation and blood was obtained 4 h later. White blood cells, neutrophils, lymphocytes, monocytes, eosinophils and basophils were evaluated. Data are presented as mean ± S.D. (n = 8–11 animals per group).
b*
p < 0.05 versus sham group.