Table 2.
Effect of hemorrhagic shock and IKK16 treatment on red blood cells and platelet parameters.a
| Sham + Vehicle | Sham + IKK16 | HS + Vehicle | HS + IKK16 | |
|---|---|---|---|---|
| RBC (M/μL) | 6.29 ± 0.38 | 6.11 ± 0.56 | 6.67 ± 0.64 | 6.61 ± 0.59 |
| HGB (g/L) | 13.15 ± 0.59 | 12.73 ± 0.83 | 13.89 ± 1.24 | 13.76 ± 1.38 |
| HCT (%) | 40.45 ± 1.64 | 39.13 ± 3.84 | 42.88 ± 5.20 | 42.30 ± 4.45 |
| MCV (fL) | 64.43 ± 2.29 | 64.07 ± 0.64 | 64.20 ± 3.67 | 63.98 ± 2.48 |
| MCH (pg) | 20.93 ± 0.74 | 20.90 ± 0.61 | 20.85 ± 0.81 | 20.81 ± 0.74 |
| MCHC (g/L) | 32.52 ± 0.87 | 32.60 ± 1.14 | 32.52 ± 1.16 | 32.53 ± 0.52 |
| RDW-SD (fL) | 32.12 ± 1.51 | 33.67 ± 1.65 | 32.68 ± 1.61 | 32.10 ± 1.64 |
| RDW-CV (%) | 16.13 ± 1.09 | 16.80 ± 1.75 | 17.45 ± 1.73 | 16.92 ± 1.29 |
| RET# (k/μL) | 462.68 ± 67.6 | 522.3 ± 147.8 | 501.7 ± 72.4 | 479.8 ± 59.4 |
| RET (%) | 7.40 ± 1.27 | 8.49 ± 1.85 | 7.53 ± 0.90 | 7.29 ± 0.95 |
| PLT (k/μL) | 990.50 ± 177.2 | 1087.3 ± 49.7 | 830.9 ± 300.7 | 954.8 ± 126.6 |
| PDW (fL) | 8.38 ± 0.57 | 8.57 ± 0.47 | 8.85 ± 0.76 | 8.60 ± 0.50 |
| MPV (fL) | 7.42 ± 0.29 | 7.43 ± 0.23 | 7.75 ± 0.52 | 7.60 ± 0.23 |
| P-LCR (fL) | 8.87 ± 1.92 | 9.03 ± 1.23 | 11.05 ± 3.24 | 9.47 ± 1.51 |
| PCT (%) | 0.73 ± 0.10 | 0.80 ± 0.04 | 0.64 ± 0.22 | 0.72 ± 0.09 |
a
Rats were subjected to HS and received IKK16 (1 mg/kg; i.v.) or vehicle (10% DMSO) at the resuscitation and blood was obtained 4 h later. Data are presented as mean ± S.D. (n = 8–11 animals per group).