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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2015 Nov;74(11):1042–1052. doi: 10.1097/NEN.0000000000000248

Figure 2.

Figure 2

Macroscopic findings of the proband. (A) There is marked frontal atrophy, with widening of sulcal spaces (arrow) and narrowing of gyri. The frontal horn of the lateral ventricle (asterisk) is enlarged and the third ventricle is dilated. Brainstem and cerebellum are unremarkable. (B, C) Coronal sections show enlargement of the frontal horn of the lateral ventricle (asterisks) with atrophy of the corpus callosum and mild atrophy of the ventromedial caudate nucleus, as well as thinning of cortical ribbon in superior frontal and cingulate gyri (arrowheads in [B]) and insular cortices (arrowhead in [C]). There is also marked atrophy of the anteromedial temporal lobe, including the hippocampus (arrow in [C]). (D) A transverse section of the midbrain shows decreased pigmentation in the substantia nigra (arrow).