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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2015 Nov;74(11):1053–1060. doi: 10.1097/NEN.0000000000000249

Figure 2.

Figure 2

PGP9.5 immunostaining of epidermal nerve fibers (ENF) in uninfected, untreated Simian Immunodeficiency Virus (SIV)-infected, and combination antiretroviral therapy (cART)-treated SIV-infected macaques. (A) Representative image of the epidermis in the footpad of an uninfected macaque depicting an abundance of long ENF (arrows) throughout the entire epidermal area. (B) In contrast, the epidermis from an untreated SIV-infected macaque depicts a marked reduction in ENF density with few fibers reaching the stratum corneum. (C) Among cART-treated SIV-infected macaques, ENF density is reduced further, evidenced by very few nerve fibers crossing the basement membrane of the epidermis.