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. Author manuscript; available in PMC: 2015 Oct 16.
Published in final edited form as: Cell Rep. 2015 Oct 1;13(2):425–439. doi: 10.1016/j.celrep.2015.09.004

Figure 4. Acute malaria induces Th1 cytokines and activates the less functional Th1-polarized CXCR3+ Tfh subset.

Figure 4

(A–D) Percentage of CXCR5+ subsets expressing the proliferation/activation markers Ki67, CD38, HLA-DR and the co-stimulatory molecule ICOS during acute febrile malaria (acute) compared to the healthy uninfected baseline (HB). (E) Representative FACS plot showing PD-1 and CCR7 expression within antigen-experienced CXCR5+CD4+ T cells in a Malian child at the HB and during acute malaria (F) Percentage CCR7loPD-1hi cells within CXCR5+CD4+ T cells at the HB and during acute malaria. (G) Percentage CCR7loPD-1hi cells within the CXCR3+ and CXCR3− Tfh subsets at the HB and during acute malaria. (H) Plasma cytokine levels at HB and acute. P values determined by paired-design ANOVA with Sidak corrections for multiple comparisons (A-D) or paired Student’s t test with Bonferroni corrections for multiple comparisons where appropriate (F–H). ****P<0.0001, ***P<0.001, **P<0.01, *P<0.05, ns=not significant