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. 2015 Oct 15;6(1):28. doi: 10.1186/s40543-015-0071-4

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© Yoo and Kwon. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — A model for self-renewal of NSCs and CSCs through asymmetric cell division. NSCs and CSCs maintain their populations in tissues or tumors through asymmetric self-renewal cell division in which one daughter cell possesses stem cell properties and the other undergoes differentiation. Through this mechanism, stem cells achieve the production of both self-renewing and differentiating cells in a single cell division. The two types of stem cells are thought to share molecular mechanisms that control asymmetric self-renewal cell division. Generally, asymmetric cell division is regulated by two types of mechanisms, intrinsic and extrinsic. Modified from (Romano 2009)