Fig. 7.
PPMs of clinical group trajectories compared to normal aging. PPMs are shown for differences of trajectory slopes in groups of 108 sMCI (top row), 92 pMCI (middle row) and 95 AD (bottom row) subjects compared to slopes in the NO group with 140 subjects. As with directed comparisons using one-sided t-tests in GLM, here we only depict the contrast for steeper slopes in the clinical groups. This contrast addresses the hypothesis that AD and MCI pathology produces faster volume loss for GM and WM volumes and faster volume increase in CSF volumes compared to normal aging. Columns depict PPMs of GM, WM and CSF tissue maps respectively. Color bars denote parameter contrast values cTθ, i.e. slope in NO minus slope in sMCI, pMCI and AD respectively. Because CSF shows growth, the sign of the contrast was reversed.