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Parametric analysis of trajectory slope variability using an ApoE4 risk score in NO (top row) and sMCI (bottom row) subjects. The applied ApoE4 risk score counts the number of ApoE4 alleles, 0, 1, or 2 respectively. PPMs with contrasts for a steeper local GMV decline (left column) and CSFV growth (right column) with increased risk are shown. Color bars denote parameter contrast values Cθ, with C containing a (minus) one for the ApoE4 regressor and zero elsewhere.
