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. 2015 May 7;146(2):265–280. doi: 10.1093/toxsci/kfv091

FIG. 2.

FIG. 2.

Caspase activation in response to DCLF/cytokine and IBU/cytokine treatment. HepG2 cells were treated with (A) a representative AA derivative (DCLF: 250 μM) or (B) a representative PA derivative (IBU: 6 mM) alone or in combination with TNFα and/or IFNγ, and cell lysates were collected 24 h after treatment for measurement of caspase 3 activity. a, significantly different from VEH; b, significantly different from TNFα; c, significantly different from IFNγ; d, significantly different from control. Data are represented as mean ± S.E.M of at least 3 separate experiments.VEH, vehicle; TNF, tumor necrosis factor-alpha; IFN, interferon-gamma; DCLF, diclofenac; IBU, ibuprofen.