Table 1.
NSAID Subclass and Maximal Plasma Concentration (Cmax) From Therapeutic Doses in Human Patients
| NSAID | Structural Sub-class | IDILI Potential | Cmax (μg/ml) | Molecular Weight (g/mol) | Cmax Reference |
|---|---|---|---|---|---|
| DCLF | AA derivative | Yes | 2.4 | 296.15 | Xu et al. (2008) |
| SLD sulfide | AA derivative | Yes | 1.6 | 340.41 | Reid et al. (2008) |
| BRM | AA derivative | Yes | 4.8 | 356.15 | Gumbhir-Shah et al. (1997) |
| IBU | PA derivative | Yes | 32.9 | 206.29 | Bramlage and Goldis (2008) |
| NAP | PA derivative | Yes | 75.9 | 252.23 | Setiawati et al. (2009) |
| Aspirin | Salicylic acid derivative | No | 7.6 | 180.16 | Brandon et al. (1986) |