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. 2015 Oct;185(10):2641–2652. doi: 10.1016/j.ajpath.2015.06.016

Figure 3.

Figure 3

Brain injury induces serum amyloid A1 (SAA1) mRNA expression in the liver. A: Quantitative PCR analysis indicates that liver SAA1 mRNA expression is highest 1 day postinjury (dpi). B–D: Vehicle or telmisartan (Telm) was administered to mice daily until sacrifice. No changes at 6 hours after injury (B). At 1 dpi (C) and 3 dpi (D), telmisartan treatment trends toward a decrease in SAA1 expression compared with mice treated with vehicle (not significant, P = 0.06). SAA1 mRNA expression was normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA. Values are expressed as means ± SEM. n = 5 to 8 per group. ∗P < 0.05, ∗∗P < 0.005, and ∗∗∗∗P < 0.0001 for SAA1 in injured mice compared with control mice. CCI, cortical impact injury.