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. 2015 Oct 16;5:225. doi: 10.3389/fonc.2015.00225

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Copyright © 2015 Krenn and Musacchio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural organization of the CPC. (A) Schematic representation of human CPC subunits with main structural features. (B) Structural organization of the localization module of the CPC (PDB ID 2QFA) (77) and of the catalytic module (PDB ID 2BFX) (70). The linker between the N- and C-terminal regions of INCENP encompasses more than 800 residues. (C) Sequence of the putative coiled-coil region of INCENP shows that its features are hardly compatible with coiled-coil folding (due to insufficient number and irregular spacing of hydrophobic residues). pI defines isoelectric point.