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. 2015 Oct 16;5:225. doi: 10.3389/fonc.2015.00225

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Copyright © 2015 Krenn and Musacchio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of CPC recruitment to centromeres. (A) Crystal structure of the complex of Survivin with a peptide encompassing the N-terminal region of Histone H3 (PDB ID 4A0J). The peptide has sequence Ala-Arg-Thr(P)-Lys, where (P) indicates that Thr3 is phosphorylated. Asp71 (D71) is implicated in the recognition of the free N-terminus of Ala2 (the N-terminal Met1 is removed by an aminopeptidase). (B) Haspin kinase phosphorylates Thr3 of histone H3 (H3-T3-P) in the centromere region to allow recruitment of the CPC. Bub1 kinase phosphorylates Histone H2A on Thr120 (H2A-T120-P) near kinetochores (i.e., the modification does not extend to centromeres). In principle, both H3-containing and CENP-A containing nucleosomes may contain this modification.