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. 2015 Oct 16;6:1134. doi: 10.3389/fmicb.2015.01134

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Copyright © 2015 Grguric-Smith, Lee, Gandhi, Brennan, DeLeon-Rodriguez, Coelho, Han and Martinez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neutropenic mice with Acinetobacter baumannii (Ab) wound infection have reduced wound healing rate. (A) Wounds of Balb/c mice isotype-matching mAb-treated (control IgG2a), mAb 1A8-treated (1A8), control IgG2a-treated A. baumannii-infected (control IgG2a + A. baumannii), and mAb 1A8-treated A. baumannii-infected (1A8 + A. baumannii), 3 and 7 days post-wounding and infection. Scale bar: 5 mm. (B) Wounded surface analysis of Balb/c mice skin lesions. For control and 1A8 groups, time points are the averages of the results for five measurements, and error bars denote standard deviations. For control IgG2a + A. baumannii and 1A8 + A. baumannii groups, time points are the averages of results for seven clinical isolates (n = 7) and error bars denote standard deviations. Symbols (∗, #, ϕ relative to control IgG2a + A. baumannii, 1A8, and control IgG2a, respectively) denote P-value significance (P < 0.01) calculated by analysis of variance (ANOVA). This experiment was performed twice with similar results obtained.