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. 2015 Oct 16;5:15221. doi: 10.1038/srep15221

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Copyright © 2015, Macmillan Publishers Limited

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(A) GSI (gamma secretase inhibitor, an inhibitor of Notch receptor processing) treatment suppresses Hes1 mRNA expression which shows the effect of GSI on Notch signaling in decidual macrophages. *P ≤ 0.05 Significant difference vs. control. (B) M1 and M2 macrophage profile associated cytokines and chemokine were measured by Luminex assay in medium from decidual macrophages recovered from mouse on day 14.5 of normal pregnancy, cultured ex vivo and treated with PBS and PGN+poly(I:C) for 2 h, followed by treatment with either control or GSI for 10 h. N = 3 each group. Error bars = ± SEM. *P ≤ 0.05, **P ≤ 0.01 Significant difference between PGN+poly(I:C) treated with control/GSI.