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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Thromb Thrombolysis. 2015 Apr;39(3):288–294. doi: 10.1007/s11239-015-1185-7

Table 3.

Suggestions for laboratory measurement of edoxaban

Clinical objective
Determine whether clinically relevant below on-therapy drug levels are present
 Estimate drug levels within the on-therapy range
 Determine whether above on-therapy drug levels are present
Suggested test Comments Suggested test Comments Suggested test Comments
Anti-Xa A normal anti-Xa likely excludes clinically relevant drug levels. A normal PT or APTT cannot be assumed to exclude clinically relevant drug levels. Anti-Xa Measurement of anti-Xa activity permits quantification of drug levels within the on-therapy range. Anti-Xa, PT Drug quantification may be less reliable with anti-Xa at above on-therapy levels. A normal PT likely excludes excess drug levels.

APTT activated partial thromboplastin time, PT prothrombin time