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. Author manuscript; available in PMC: 2015 Dec 25.
Published in final edited form as: Nature. 2015 Jun 15;522(7557):450–454. doi: 10.1038/nature14471

Figure 3. Interactions of Emi1 with Apc2CTD-Apc11RING and D box receptor of Cdh1 and Apc10.

Figure 3

(a) and (b) views of the EM density and underlying secondary structure. Emi1 elements are shown: D box (Emi1D-box); Emi1Linker and Emi1ZBR interconnects Apc1PC with Apc2CTD and Apc11RING. Both Emi1Linker and Emi1ZBR block the UbcH10-binding site on Apc11, but not the Ube2S-specific site 26. The C-terminal LRRL tail (Emi1LR) of Emi1 binds to Apc2CTD.