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. 2015 Jun 24;4(7):e001598. doi: 10.1161/JAHA.114.001598

Figure 2.

Figure 2

Apocynin attenuated cardiac fibrosis, expression of fibroblast growth factor-2, malondialdehyde and NOX activity in STNx rats. A, Representative Masson staining micrographs show that the increased cardiac interstitial fibrosis in STNx rats was attenuated by apocynin (bar=200 μm). B, Bar graph shows the interstitial fibrosis volume fractions (n=40 fields). C, The expression level of cardiac FGF-2 (n=6). D, MDA levels in left ventricular tissue homogenates (n=6). E, NOX activity was measured with lucigenin-enhanced chemiluminescence assay. The NOX activities in different groups were normalized to controls (n=4). Data were expressed as mean±SD. *P<0.01 vs Sham group; #P<0.01 vs STNx group. FGF-2 indicates fibroblast growth factor-2; GAPDH, anti–glyceraldehyde 3-phosphate dehydrogenase; MDA, malondialdehyde; NOX, nicotinamide adenine dinucleotide phosphate oxidase; STNx, 5/6 subtotally nephrectomized.