Table 3.
Survival Rate, Plasma Ang II, and Echocardiographic Parameters in Rats at Week 8 After Surgery
| Sham Operated(n=10) | STNx(n=10) | STNx+Apocynin(n=10) | |
|---|---|---|---|
| Survival rate | 10/10 | 10/13 | 10/12 |
| Ang II, ng/L | 281 (152, 359) | 412 (251, 576)* | 320 (172, 441)† |
| Body weight, g | 360±24 | 259±20* | 290±23*† |
| LV weight, g | 0.59±0.05 | 0.82±0.05* | 0.65±0.03*† |
| LV/body weight, g/kg | 1.70±0.13 | 3.20±0.21* | 2.14±0.16*† |
| LVPWd, mm | 1.13±0.03 | 1.36±0.09* | 1.25±0.07*† |
| LVEDD, mm | 7.48±0.49 | 7.685±0.62 | 7.49±0.43 |
| LVESD, mm | 4.87±0.33 | 5.98±0.35* | 5.07±0.24† |
| FS% | 32.2±1.3 | 21.9±2.7* | 28.7±2.0*† |
| EF% | 65.1±2.4 | 49.2±4.7* | 61.1±4.4† |
Ang indicates angiotensin II; STNx, 5/6 subtotally nephrectomized; LV, left ventricular; LVPWd, left ventricular posterior wall thickness at diastole; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; FS, fraction shortening; EF, ejection fraction.
P<0.01 vs sham-operated group.
P<0.01 vs STNx group.