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The absence of SAA reduces atherosclerosis in the ascending aorta. Saa−/−Ldlr−/− and Ldlr−/− mice were fed a Western-type diet for (A) 6 or (B) 12 weeks. Lesions in the ascending aorta, innominate artery, and aortic root were stained with oil red O, and cross-sectional area was quantified. Each dot represents an individual mouse. n=9 to 13 for each group in (A) and 8 to 11 for each group in (B). *P<0.02. SAA indicates serum amyloid A.
