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. 2015 Jul 15;4(7):e001974. doi: 10.1161/JAHA.115.001974

Figure 3.

Figure 3

Adrenergic sensitivity. A, GSNOR−⁄− mice (n=7) post MI have lower isoproterenol sensitivity during PV loop compared with WT mice (n=9). GSNOR−⁄− mice do not exhibit changed heart parameters after 40 ng/kg per minute of isoproterenol injection into jugular vein. WT mice responded to isoproterenol infusion (1 way ANOVA). B, Dose-response to isoproterenol in GSNOR−⁄− cardiomyocytes (n=6) is right-shifted compared with WT (n=6), exhibiting a reduced sensitivity to β-adrenergic stimulation, with conserved maximal contraction (nonlinear regression dose-response fit; P=0.0318). Data are presented as mean±SEM. ANOVA indicates analysis of variance; BL, Baseline; GSNOR, S-nitrosoglutathione reductase; MI, myocardial infarction; PRSW, preload recruitable stroke work; WT, wild-type.