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. 2015 Jul 15;4(7):e001974. doi: 10.1161/JAHA.115.001974

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Enhanced proliferative expansion of cardiomyocytes in GSNOR^−⁄− hearts post MI A and B, BrdU incorporation by cardiomyocytes in WT (A, arrows) and GSNOR^−⁄− (B, arrowheads) hearts, 1 month post MI. C, Quantification of BrdU⁺ cardiomyocytes reveals that, compared with WT,GSNOR^−⁄− hearts are characterized by a 3-fold increase in cardiomyocyte proliferation in their infarct zone (IZ) (1-way ANOVA, *P<0.0001). Values are mean±SEM. ANOVA indicates analysis of variance; BrdU, 5-bromodeoxyuridine; BZ, border zone; CMs, cardiomyocytes; GSNOR, S-nitrosoglutathione reductase; MI, myocardial infarction; RZ, remote zone; WT, wild-type.