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. 2015 Jul 15;4(7):e001974. doi: 10.1161/JAHA.115.001974

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Enhanced neovascularization in post MI GSNOR^−⁄− hearts. A, Representative immunofluorescent images of isolectin-IB4 in WT (left panel) and GSNOR^−⁄− (right panel) hearts, 2 months post MI. B, BrdU incorporation in coronary vascular cells of a GSNOR^−⁄− heart, demonstrates the presence of newly regenerated coronary vessels 1 month post MI. C, Quantification of isolectin-IB4⁺ vessels demonstrates that GSNOR^−⁄− mice are characterized by a significantly enhanced vascular density compared with WT (1-way ANOVA, *P<0.0001). Values are mean±SEM. ANOVA indicates analysis of variance; BrdU, 5-bromodeoxyuridine; BZ, border zone; GSNOR, S-nitrosoglutathione reductase; IZ, infarct zone; MI, myocardial infarction; RZ, remote zone; WT, wild-type.