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. 2015 Jul 27;4(7):e002044. doi: 10.1161/JAHA.115.002044

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© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Regions of interest for DEMRI and MEMRI. Representative (A and B) short-axis DEMRI and (C) MEMRI images showing semiautomatic tracing of ROIs in a pig heart 6 weeks after human amniotic mesenchymal stem cell delivery. The signal threshold standard deviation method was used for DEMRI and MEMRI quantification with manual correction. Note the overall smaller MEMRI-defect area (blue ROI) compared with the yellow DEMRI-positive region. (D) Superimposed DEMRI and MEMRI infarct ROIs show the extent of PIR on either edge of the positive DEMRI regions still labeled yellow. DEMRI indicates delayed gadolinium enhancement magnetic resonance imaging; MEMRI, manganese-enhanced magnetic resonance imaging; PIR, peri-infarct region; ROI, region of interest.