Fig. 4.

Attenuation of insulin signaling under conditions of increased BMI as derived from the mRNA abundances as determined in the present study. Green and red coloring indicates negative and positive correlation of the gene-specific transcripts specifying the corresponding proteins/protein complexes shown here with BMI. Labeled are those insulin signaling modules whose decrease or increase on the protein level is predicted to contribute to or to be indicative of attenuated transduction of the insulin signal. Illustration adopted and modified by courtesy of Cell Signaling Technology/New England Biolabs