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. 2015 Oct 15;8:66. doi: 10.1186/s12920-015-0142-9

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© Campbell et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — An integrated visualization of the top two networks generated by IPA. The connections between genes in the NK cell signaling pathways have been highlighted using blue edges. Red nodes represent up-regulated genes, and green nodes represent down-regulated genes identified in our differential expression analysis (based on NK cells dual-stimulated via IgG and IL-12). The darker the node color, the more extreme (high or low) the up- or down-regulation of the respective gene. White nodes represent genes that were not originally identified in our microarray analysis but are connected to other genes within the enriched network. Blue nodes represent genes from canonical pathways. Relationship types are outlined in the figure legend