Table 2.
Synthesis of PEG-based hybrid hydrogels by click reactions.a)
No. | PEG-4N3
M̄n
|
Dialkyne peptide | PEG Conc, w/v
|
Gelation time | Yieldb) |
---|---|---|---|---|---|
g · mol−1 | % | % | |||
1 | 8 800 | GFLG1 | 2.5 | no gel | – |
2 | 8 800 | GFLG1 | 5 | h | 66.9 |
3 | 8 800 | GFLG1 | 10 | 12 minc) | 94.6 |
4 | 8 800 | GFLG2 | 10 | 9 minc) | 58.1 |
5 | 2 100 | GFLG1 | 10 | 9 minc) | 56.8 |
6 | 2 100 | GFLG2 | 10 | ≈l0 minc) | 45.1 |
Experimental conditions: [azide]0/[alkyne]0/[CuBr]0/[L-ascorbic acid]0 = 1:1:0.5:0.25; rt in DMF;
Yield = (weight of dried gel)/(initial weight of PEG-4N3 + initial weight of dialkyne peptide);
Gelation time was obtained from dynamic time-sweep rheology experiments.