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. Author manuscript; available in PMC: 2015 Oct 16.
Published in final edited form as: Macromol Biosci. 2010 Apr 8;10(4):445–454. doi: 10.1002/mabi.200900295

Table 2.

Synthesis of PEG-based hybrid hydrogels by click reactions.a)

No. PEG-4N3 n
Dialkyne peptide PEG Conc, w/v
Gelation time Yieldb)
g · mol−1 % %
1 8 800 GFLG1 2.5 no gel
2 8 800 GFLG1 5 h 66.9
3 8 800 GFLG1 10 12 minc) 94.6
4 8 800 GFLG2 10 9 minc) 58.1
5 2 100 GFLG1 10 9 minc) 56.8
6 2 100 GFLG2 10 ≈l0 minc) 45.1
a)

Experimental conditions: [azide]0/[alkyne]0/[CuBr]0/[L-ascorbic acid]0 = 1:1:0.5:0.25; rt in DMF;

b)

Yield = (weight of dried gel)/(initial weight of PEG-4N3 + initial weight of dialkyne peptide);

c)

Gelation time was obtained from dynamic time-sweep rheology experiments.