Table 1.
Sample of training data records indicating the composition and properties of CAR nanosuspensions
| Record | Drug load (mg) | Stabilizer typea | Stabilizer HLB | Stabilizer molecular weight | PEOb | PPOc | PEO/PPO ratio | Weight of stabilizer (mg) | Drug/stabilizer ratiod | Phase volume ratio | Water volume (mL) | Average PS ± SD (nm) | Average PDI ± SD | Average ZP ± SD (mV) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 25.00 | 1.00 | 22.00 | 12,600.00 | 198.00 | 65.00 | 3.05 | 50.00 | 0.50 | 10.00 | 50.00 | 270.75±10.11 | 0.15±0.07 | −5.88±0.25 |
| 2 | 25.00 | 1.00 | 22.00 | 12,600.00 | 198.00 | 65.00 | 3.05 | 50.00 | 0.50 | 4.00 | 20.00 | 1,192.00±26.87 | 1.00±0.00 | −15.25±1.63 |
| 3 | 25.00 | 1.00 | 22.00 | 12,600.00 | 198.00 | 65.00 | 3.05 | 100.00 | 0.25 | 10.00 | 50.00 | 495.45±31.60 | 0.46±0.01 | −14.90±1.44 |
| 4 | 25.00 | 1.00 | 22.00 | 12,600.00 | 198.00 | 65.00 | 3.05 | 100.00 | 0.25 | 4.00 | 20.00 | 1,542.50±38.89 | 0.39±0.04 | −14.80±2.03 |
| 5 | 25.00 | 1.00 | 22.00 | 12,600.00 | 198.00 | 65.00 | 3.05 | 75.00 | 0.33 | 10.00 | 50.00 | 395.60±6.08 | 0.18±0.03 | −8.93±0.89 |
| 6 | 25.00 | 1.00 | 22.00 | 12,600.00 | 198.00 | 65.00 | 3.05 | 75.00 | 0.33 | 4.00 | 20.00 | 918.75±3.18 | 0.29±0.00 | −15.10±1.15 |
| 7 | 25.00 | 2.00 | 24.00 | 8,400.00 | 152.00 | 30.00 | 5.07 | 50.00 | 0.50 | 10.00 | 50.00 | 850.00±22.54 | 0.74±0.17 | −18.70±0.14 |
| 8 | 25.00 | 2.00 | 24.00 | 8,400.00 | 152.00 | 30.00 | 5.07 | 50.00 | 0.50 | 4.00 | 20.00 | 3,200.00±75.12 | 1.00±0.00 | −19.20±1.56 |
| 9 | 25.00 | 2.00 | 24.00 | 8,400.00 | 152.00 | 30.00 | 5.07 | 100.00 | 0.25 | 10.00 | 50.00 | 399.75±14.29 | 0.44±0.03 | −19.00±0.73 |
| 10 | 25.00 | 2.00 | 24.00 | 8,400.00 | 152.00 | 30.00 | 5.07 | 100.00 | 0.25 | 4.00 | 20.00 | 798.00±62.23 | 0.49±0.09 | −26.70±1.26 |
| 11 | 25.00 | 2.00 | 24.00 | 8,400.00 | 152.00 | 30.00 | 5.07 | 75.00 | 0.33 | 10.00 | 50.00 | 339.35±17.89 | 0.25±0.10 | −19.80±1.89 |
| 12 | 12.50 | 3.00 | 12.00 | 5,750.00 | 38.00 | 69.00 | 0.55 | 37.50 | 0.33 | 4.00 | 20.00 | 361.75±21.25 | 0.40±0.02 | −10.10±0.94 |
Notes:
a
Pluronic surfactant type (1 denotes F127, 2 denotes F68, and 3 denotes P123);
b
polyethylene oxide units;
c
polypropylene oxide units; and
d
drug:stabilizer ratio (1:2, 1:3, and1:4).
Abbreviations: CAR, carvedilol; HLB, hydrophilic–lipophilic balance; PS, particle size; PDI, polydispersity index; SD, standard deviation; ZP, zeta potential.