Table 4.

Model-generated optimized solution and its analogous fresh and lyophilized experimental nanosuspensions

Solution	Desirability	Nanosuspension independent variables (inputs)						Dependent variables (output properties)
		X1	X2	X8	X9	X10	X11	Y1	Y2	Y3
		Drug load (mg)	Stabilizer type	Weight of stabilizer (mg)	Drug/stabilizer ratio	Phase volume ratio	Water volume (mL)	PS (nm)	PDI	ZP (mV)
Population 1	1.00	23	1	48.80	0.47	9	45	280.52	0.25	−9.50
Fresh NS	NA	23	1	48.80	0.47	9	45	277.90	0.19	−10.38
Lyophilized NS	NA	23	1	48.80	0.47	9	45	316.40	0.20	−8.94

Abbreviations: NS, nanosuspension; PS, particle size; PDI, polydispersity index; ZP, zeta potential; NA, not applicable.