Table 2.
ORs and heterogeneity results for CYP1A1 meta-analysis
| SNP | Cancer | Ethnicity | n | Genetic model | I2 | Contrast model | P, ORs (95% CIs) |
|---|---|---|---|---|---|---|---|
| T3801C | ALL | Caucasian | 8 | Recessive | 26% | Fixed effects | 0.28, 1.31 (0.81, 2.12) |
| Dominant | 61% | Random effects | 0.10, 1.30 (0.95, 1.79) | ||||
| Allele contrast | 32% | Fixed effects | 0.05, 1.18 (1.00, 1.39) | ||||
| Asian | 4 | Recessive | 63% | Random effects | 0.73, 1.14 (0.54, 2.39) | ||
| Dominant | 68% | Random effects | 0.06, 1.64 (0.98, 2.73) | ||||
| Allele contrast | 80% | Random effects | 0.19, 1.35 (0.86, 2.14) | ||||
| Mix | 4 | Recessive | 76% | Random effects | 0.21, 2.68 (0.57, 12.62) | ||
| Dominant | 82% | Random effects | 0.32, 1.34 (0.75, 2.39) | ||||
| Allele contrast | 92% | Random effects | 0.34, 1.42 (0.69, 2.91) | ||||
| A2455G | ALL | Caucasian | 4 | Recessive | 0% | Fixed effects | 0.002, 2.23 (1.36, 3.68) |
| Dominant | 39% | Fixed effects | 0.12, 1.22 (0.95, 1.58) | ||||
| Allele contrast | 41% | Fixed effects | 0.010, 1.31 (1.07, 1.61) | ||||
| Asian | 3 | Recessive | 11% | Fixed effects | 0.14, 1.57 (0.87, 2.83) | ||
| Dominant | 72% | Random effects | 0.29, 1.40 (0.76, 2.59) | ||||
| Allele contrast | 0% | Fixed effects | 0.89, 1.02 (0.80, 1.29) | ||||
| Mix | 1 | Recessive | Fixed effects | ||||
| Dominant | Fixed effects | 0.94, 1.03 (0.45, 2.34) | |||||
| Allele contrast | Fixed effects | 0.94, 1.03 (0.47, 2.26) | |||||
| C4887A | ALL | Caucasian | 1 | Recessive | Fixed effects | 0.61, 1.67 (0.23, 11.99) | |
| Dominant | Fixed effects | 0.14, 0.57 (0.27, 1.21) | |||||
| Allele contrast | Fixed effects | 0.22, 0.65 (0.33, 1.30) | |||||
| T3801C | AML | Caucasian | 4 | Recessive | 0% | Fixed effects | 0.26, 1.74 (0.66, 4.55) |
| Dominant | 47% | Fixed effects | 0.16, 0.82 (0.62, 1.08) | ||||
| Allele contrast | 59% | Random effects | 0.63, 0.90 (0.59, 1.37) | ||||
| Asian | 3 | Recessive | 0% | Fixed effects | 0.60, 0.93 (0.71, 1.22) | ||
| Dominant | 0% | Fixed effects | 0.03, 1.26 (1.02, 1.55) | ||||
| Allele contrast | 0% | Fixed effects | 0.23, 1.09 (0.95, 1.26) | ||||
| Mix | 3 | Recessive | 0% | Fixed effects | 0.72, 1.19 (0.46, 3.05) | ||
| Dominant | 74% | Random effects | 0.65, 1.24 (0.48, 3.22) | ||||
| Allele contrast | 72% | Random effects | 0.81, 1.11 (0.48, 2.55) | ||||
| A2455G | AML | Caucasian | 1 | Recessive | |||
| Dominant | Fixed effects | 0.47, 0.78 (0.39, 1.53) | |||||
| Allele contrast | Fixed effects | 0.48, 0.78 (0.40, 1.53) | |||||
| Asian | 1 | Recessive | Fixed effects | 0.39, 0.79 (0.47, 1.35) | |||
| Dominant | Fixed effects | 0.42, 1.09 (0.88, 1.36) | |||||
| Allele contrast | Fixed effects | 0.72, 1.03 (0.87, 1.23) | |||||
| Mix | 2 | Recessive | 0% | Fixed effects | 0.50, 1.64 (0.39, 6.92) | ||
| Dominant | 0% | Fixed effects | 0.0009, 1.96 (1.32, 2.90) | ||||
| Allele contrast | 0% | Fixed effects | 0.002, 1.72 (1.22, 2.43) | ||||
| C4887A | AML | Caucasian | 1 | Recessive | Fixed effects | 0.39, 2.85 (0.26, 31.63) | |
| Dominant | Fixed effects | 0.005, 2.16 (1.27, 3.69) | |||||
| Allele contrast | Fixed effects | 0.004, 2.08 (1.26, 3.44) | |||||
| A2455G | CML | Caucasian | 2 | Recessive | 17% | Fixed effects | 0.004, 19.61 (2.62, 146.76) |
| Dominant | 69% | Random effects | 0.0010, 3.93 (1.74, 8.87) | ||||
| Allele contrast | 1% | Fixed effects | P,0.00001, 3.92 (2.61, 5.90) | ||||
| Mix | 1 | Recessive | Fixed effects | 0.89, 0.80 (0.03, 20.00) | |||
| Dominant | Random effects | 0.79, 0.88 (0.34, 2.29) | |||||
| Allele contrast | Fixed effects | 0.70, 0.84 (0.34, 2.07) |
Abbreviations: ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CI, confidence interval; CML, chronic myeloid leukemia; OR, odds ratio; SNP, single nucleotide polymorphism.