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Schematic illustration of preparation of hyaluronic acid-conjugated silica nanoparticles.
Notes: 5-fluorouracil was used as a model drug to load in the nanoparticles. The carboxylic group of HA was activated and conjugated with the amine functional group of silica nanoparticles.
Abbreviations: HA, hyaluronic acid; 5-FU, 5-fluorouracil; NP, nanoparticles.
