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In vitro release profile of 5-FU/SNP and 5-FU/HSNP in phosphate-buffered saline (pH =7.4) at 37°C.
Notes: The release study was conducted up to 120 hours, and the amount of drug released was evaluated by means of HPLC technique. *P<0.05.
Abbreviations: HPLC, high performance liquid chromatography; 5-FU, 5-fluorouracil; HSNP, hyaluronic acid-conjugated silica nanoparticles; SNP, silica nanoparticles.
