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. 2015 Oct 12;10:6445–6454. doi: 10.2147/IJN.S89476

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© 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cytotoxicity assay.

Notes: (A) The toxicity of blank nanoparticles on colo-205 cancer cells, (B) cytotoxicity of 5-FU, 5-FU/SNP, and 5-FU/HSNP in colo-205 colon cancer cells. All experiments were done by MTT assay in four replicates from three independent experiments. Data was represented as mean ± SD. (C) Morphological images of cancer cells upon treatment with the respective formulations. *P<0.05.

Abbreviations: 5-FU, 5-fluorouracil; HSNP, hyaluronic acid-conjugated silica nanoparticles; SNP, silica nanoparticles; NP, nanoparticles.