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. 2015 Oct 16;10(10):e0140452. doi: 10.1371/journal.pone.0140452

Fig 5. A-769662 treatment also abrogated joint damage and IL-6 expression in AIA.

Fig 5

(A) Representative H&E and Safranin O stained sections of knee joints on day 10 of AIA induction in vehicle and A-769662-treated mice, which were treated either at day 0 or day 4 after intraarticular injection of mBSA (n = 5 mice per group). Original magnification 200x. (B) Knee thickness in A-769662-treated mice on day 10 of AIA induction. (C) Sections of knee joints were scored for inflammatory infiltration, bone erosion and cartilage damage. A-769662-treated mice had significantly lower scores than WT. (D) Proteins of joint tissues from naive (n = 3 mice per group) and arthritic mice (n = 5 mice per group) of vehicle and A-769662-treated mice were extracted and analyzed by ELISA for the presence of IL-6. (E) Serum from naive (n = 3 mice per group) and arthritic mice (n = 5 mice per group) of vehicle and A-769662-treated mice was analyzed by ELISA for IL-6. Results are expressed as means ± SEM.* p< 0.05 vs WT mice; ** p<0.01