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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2015 Mar 31;26(6):924–933. doi: 10.1007/s13361-015-1131-0

Figure 1.

Figure 1

Sputtered silver MALDI-IM-MS analysis of cholesterol standard on an ITO-coated glass MALDI plate. (a) Scanning electron microscopy image of nanoparticles formed from sputtered silver. Average particle size is approximately 20 nm. (b) Two-dimensional IM-MS spectrum of cholesterol standard. Cholesterol-silver adducts are highlighted in the white box. (c) Mass spectrum of cholesterol-silver adducts without IM separation (i.e., integrated across all drift times between m/z 488 and 498). Peaks corresponding to cholesterol and related species are labeled “C” and chemical noise is labeled with asterisks *. (d) Mass spectrum of cholesterol-silver adducts over the ion mobility drift time region indicated by dashed lines in (a). Significant S/N improvement of cholesterol is achieved via exclusion of chemical noise