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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2015 Aug 4;39(9):1582–1601. doi: 10.1111/acer.12805

Table 1. Characteristics of published studies examining alcohol and illicit drug use in post-bariatric populations.

Study Research Design
  1. Study Design

  2. Assessment Time Points

Sample
  1. N

  2. Recruitment Design

  3. Inclusion Criteria

  4. Baseline Response Rate

  5. Retention Rate

  6. Surgery Type

  7. Age

  8. Sex

  9. Race/Ethnicity

Methods
  1. Assessment instrument(s)

  2. Assessment method(s)

Substance Use Outcomes Measured
Svensson et al., 2013
  1. Prospective; longitudinal

  2. Baseline (4 months prior to surgery for surgery group) .5, 1, 2, 3, 4, 6, 8, 10, 15, and 20 years follow-up

  1. Surgery group =2,010; non-surgical control group = 2,037

  2. Sample derived from Swedish Obese Subjects (SOS) trial; recruited from media campaigns and health care centers

  3. Identical inclusion/exclusion criteria for both surgery and control groups: eligible for bariatric surgery, between 37 and 60 years; BMI ≥ 34 men and ≥ 38 for women

  4. n.d.

  5. n.d. .5 yrs., n.d. 1 yr., 87% 2 yrs., 71% 10 yrs., 52% 15 yrs., 50% 20 yrs.

  6. GBP = 265; 376=AGB; VBG =1,369

  7. Mean age (S.D.): GBP= 47 (6.0); AGB=47.6 (6.0); VBG=47.1 (5.9)

  8. Males: GBP=28.7 %, AGB=30.9 %, VBG=29.1 %

  9. N.D. (conducted in Sweden)

  1. SOS dietary questionnaire (assessed intake of food and beverages in past 3 months); self-reported alcohol use problems were assessed with an affirmative response to “Do you think you have alcohol problems?”; alcohol abuse diagnosis obtained from medical records

  2. Self-reported data (alcohol use frequency and problems with alcohol) and chart review (alcohol abuse diagnosis) N.D. provided if assessments were self-administered or interviewer/clinician administered

  1. Post-surgical problematic alcohol use/alcohol use disorder

  2. Post-surgical alcohol use/frequency of alcohol use

  3. Quantity of alcohol intake

King et al., 2012
  1. Prospective; longitudinal

  2. Baseline (pre-surgery), 1, and 2 years post-surgery

  1. n=1945

  2. Sample recruited from participating surgeons at 10 centers across the U.S.

  3. Patients > 18 years old, seeking bariatric surgery

  4. 79% completed baseline and first and/or 2nd year post-operative assessment

  5. See above

  6. 69.6%=RYGB, 25.2% = AGB 4.9% = other

  7. Median age (range)=47 (38-55)

  8. 78.8%=female; 21.2%=male

  9. 87% white; 9.4% black; 4.9% Hispanic

  1. Alcohol Use Disorders Identification Test (AUDIT); scored an 8 or higher on AUDIT, or at least 1 symptom of alcohol related harm or alcohol dependence

  2. Self-reported; in-person interview

  1. Pre-surgical history of problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Post-surgical alcohol use/frequency of alcohol use

  4. Quantity of alcohol intake

Conason et al., 2012
  1. Prospective; longitudinal

  2. Baseline (pre-surgery) and 1, 3, 6, 12, and 24 months post-surgery

  1. n=155

  2. Recruited from a pre-operation information center at one participating bariatric surgery center

  3. N.D.

  4. N.D.

  5. 61% 1 mo., 41% 3 mo., 43% 6 mo., 49% 12 mo., 25% 24 mo.

  6. n=100 RYGB; n=55 AGB

  7. Mean age = 40 (SD=11)

  8. 85% female, 15% male

  9. 47% Hispanic, 32% non-Hispanic black,17% non-Hispanic white 1% Asian; 3% other

  1. “Compulsive Behaviors Questionnaire” (developed by study authors)

  2. Self-administered questionnaire

  1. Post-surgical problematic alcohol use/alcohol use disorder

  2. Any alcohol use/frequency of alcohol use

  3. Post-surgical illicit drug use

Wee et al., 2014
  1. Prospective; longitudinal

  2. Baseline (pre-surgery), 1, and 2 years post-surgery

  1. n= 541

  2. Sample derived from Assessment of Bariatric Surgery Study (ABS); recruited from 2 WLS centers in Boston, MA.

  3. 18-65, English speaking, permission of physician

  4. 70%

  5. 69 % 1 year, 63% 2 year

  6. RYBG = 55%, AGB = 44%; ASG/other = 1%

  7. Mean age = 43.9

  8. Male = 24 %; Female = 76%

  9. 69% non-Hispanic white; 17% African American; 11% Hispanic; 4% Other

  1. Alcohol Use Disorders Identification Test – C (AUDIT-C); high-risk alcohol use defined as cut off score≥4 in men ≥3 in women, or affirmative response to follow up items of alcohol dependency (i.e., impaired control over drinking, morning drinking, etc.), or harmful drinking (i.e., others concerned about drinking, guilt after drinking, etc.).

  2. Self-reported; Telephone interviews

  1. Post-surgical problematic alcohol use/alcohol use disorder

  2. Any alcohol use/frequency of alcohol use

  3. Quantity of alcohol intake

Lent et al., 2013
  1. Prospective; longitudinal

  2. Baseline (6-12 months before surgery) & 1 time post-surgery (mean 34.9 months post-surgery; +/12.8 months)

  1. n=155

  2. RYGB patients recruited from rural integrated health system

  3. Respondents who returned a post-operative (mailed)survey and answered at least one question on recent alcohol and smoking use,

  4. 899 patients recruited, 155 (17.2%) answered at least one question on alcohol and smoking use at both pre- and post-operative assessments.

  5. 345 (38%) of 899 completed post-operative survey; of these 155 answered a question on recent smoking and alcohol use and were included in analysis

  6. 100% RYGB

  7. Mean age = 50.1(S.D=11.3 years)

  8. 80.6% female

  9. 98.1% white

  1. Substance use questionnaire created by study researchers (not validated). Questions included: “How often did you have a drink containing alcohol in the past year?” “How many drinks did you have on a typical day when you were drinking in the past year?” and “How often did you have 6 or more drinks on [one] occasion in the past year?” Alcohol use on typical drinking occasions categorized as 1) none, 2) low consumption (1-4 drinks), and 3) high consumption (≥5).

  2. Mailed, self-administered questionnaire

  1. Any alcohol use/frequency of alcohol use

Alfonsson et al., 2014
  1. Prospective; longitudinal

  2. 5 months prior to surgery (m-153 days, SD=10.52) and 12 months post-surgery (m=370, SD=77.3)post-surgery

  1. n=129

  2. Patients were recruited from a University hospital in Sweden who were eligible for RYGB

  3. N.D.

  4. N.D

  5. 100% (only complete data used in analyses).

  6. 100% RYGB

  7. Mean age =42.8 (SD=10.52)

  8. 78% female

  9. N.D. (conducted in Sweden)

  1. Alcohol Use Disorders Identification Test (AUDIT); scored an 8 (men) or 6 (women) or higher on AUDIT to indicate AUD or at least 1 symptom of alcohol related harm or alcohol dependence; Adult ADHD Self-Rating Scale (ASRS) for ADHD symptomatology

  2. Self-reported data; N.D. if assessments were self-administered or interviewer/clinician administered

  1. History of problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

Buffington, 2007
  1. Cross-sectional

  2. One time post-surgery; 84% ≥ one year post-surgery

  1. n=318

  2. Online survey

  3. Open to all readers of an online bariatric surgery journal, who had bariatric surgery

  4. N/A

  5. N/A

  6. 97.4% RYGB

  7. 49.4% between 36 and 50

  8. 93.7% female (n=298)

  9. N.D.; respondents from U.S., northern Europe, & Israel

  1. No standardized assessments; “questions pertaining to alcohol sensitivity, postoperative changes in alcohol use and clearance.”

  2. Online survey

  1. Problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Any alcohol use/frequency of alcohol use

  4. Quantity of alcohol intake

  5. Subjective sensitivity to alcohol

Ertelt et al., 2008
  1. Cross-sectional

  2. One time; 6-10 years post-bariatric surgery

  1. n=70;

  2. Surveys mailed to patients who underwent the RYGB procedure, 6-10 years ago, at one bariatric surgery center

  3. N.D.

  4. 28% (70 of 250 mailed surveys)

  5. N/A

  6. 100%= RYGB

  7. Mean age=49.9 (SD=9.2)

  8. 85.5% female

  9. 90% white

  1. Post-Bariatric Surgery Appearance Questionnaire (developed by study authors, contains questions on alcohol abuse and dependence based on DSM-IV criteria; not validated)

  2. Self-administered questionnaires mailed to participants

  1. History of problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Any alcohol use/frequency of alcohol use

  4. Quantity of alcohol intake

  5. Subjective sensitivity to alcohol

Mitchell et al., 2001
  1. Cross-sectional

  2. One time; 13-15 years post-surgery

  1. n=78

  2. Post-operative patients from one facility, contacted via postal mail and telephone

  3. N.D.

  4. 78% (100 post-operative patients attempted to be contacted)

  5. N/A

  6. 100% RYGB

  7. Mean age = 56.8 (31-77)

  8. 83% (n=65) female

  9. N.D.

  1. MFED – instrument which uses sections of Structured Clinical Interview for DSM-IV Disorders (SCID)

  2. Telephone interview

  1. History of problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Pre-surgical History of illicit drug use

  4. Post-surgical/Post-Surgical illicit drug use

Macias & Leal, 2003
  1. Cross-sectional

  2. One time; 18 months post-surgery

  1. n=140

  2. Post-operative patients from a University hospital in Spain

  3. N.D.

  4. N.D.

  5. N/A

  6. 100% VBG

  7. Binge eating group 36.46 (SD=11.72); non binge eating eating group 44.61 (SD=9.92)

  8. 78.6% female

  9. N.D. (conducted in Spain)

  1. Millon Clinical Multiaxial Inventory-II to assess alcohol dependence

  2. N.D.

  1. Post-surgical problematic alcohol use/alcohol use disorder

Suzuki et al., 2012
  1. Cross-sectional

  2. Retrospective chart review (pre-surgical data) & telephone interview (post-surgical data)

  1. n=

  2. Patients were recruited who completed pre-operative psychological evaluation at Bringham and Women's Hospital and underwent bariatric surgery between 2004 and 2007

  3. ≥ 2 years post-surgery; ≥ 18 years old

  4. 460 surveys mailed to patients; 51 agreed to participate (11.1%)

  5. N/A

  6. RYGB 54.9%, LAGB 45.1%

  7. mean age= 51 (SD=8.7; 33-68)

  8. 86.3% female

  9. N.D.

  1. Structured Clinical Interview for DSM-IV (administered post-surgery only)

  2. Chart review of pre-surgical psychiatric assessments & telephone interview post-surgery

  1. History of problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Pre-surgical history of illicit drug use

  4. Post-surgical illicit drug use

Odom et al., 2010
  1. Cross-sectional; retrospective

  2. Mailed surveys administered one time, over 1 year post-surgery

  1. n=203

  2. Surveys mailed to bariatric surgery patients identified through patient database from one hospital.

  3. N.D.

  4. 1,117 surveys mailed, 24.8% returned (n=278), 203 included in final analysis

  5. 100% RYGB

  6. Mean age = 50.6 (+/9.8 years)

  7. 85% female

  8. 71.9% white

  9. N.D.

  1. No standardized assessment. “Has your alcohol consumption increased/decreased since bariatric surgery” and “Has anyone ever expressed concern about your use of alcohol or drugs?”

  2. Retrospective chart review (pre-surgical data) & self-administered surveys sent via postal mail (post-surgical data)

  1. Post-surgical problematic alcohol use/alcohol use disorder

  2. Subjective change in alcohol use after surgery

Adams et al., 2012
  1. Medical record review

  2. Review of medical records collected pre-surgery, 6, 12, and 24 months post-surgery

  1. n=61

  2. Chart review of veterans who underwent bariatric surgery from one VA facility between 2003 and 2008.

  3. Met national VA requirements for bariatric surgery

  4. N/A

  5. N/A

  6. 59% AGB, 41% RYGB

  7. Mean age = 48 +/-7.3; 35-60)

  8. 67%=male

  9. 70%=white; 28.3% African American

  1. AUDIT-C for alcohol use diagnoses; DSM-IV based diagnosis made by licensed clinical psychologist or healthcare provider for drug use disorder(pre-surgery), and urine screen (post-surgery)

  2. Medical chart review

  1. History of problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Pre-surgical illicit drug use

  4. Post-surgical illicit drug use

Tedesco et al., 2013
  1. Medical record review

  2. Review of medical records collected pre-surgery and 2 weeks, 2 months, 6 months, and 12 months post-surgery

  1. n=205; n= 74 with a pre-surgical history of substance abuse (alcohol and drugs; SA group), n= 131 with no substance abuse history (NA group)

  2. Veterans who had undergone bariatric surgery at the Palo Alto VA from 2002 and 2011 at one Veterans Affairs hospital; identified through database review

  3. N/A

  4. N/A

  5. N/A

  6. 11.2% AGB (n= 23); 35% ASG (n=72); 53.7% RYGB (n=110)

  7. Mean age = 51.5

  8. SA group =86.5% male; NA group =73.3% male

  9. N.D.

  1. Diagnosis made by mental health professional based on DSM-IV-TR criteria

  2. Medical chart review; participants were screened for alcohol and substance abuse as a part of their regular post-op visits

  1. Pre-surgical problematic alcohol use/alcohol use disorder

  2. Post-surgical problematic alcohol use/alcohol use disorder

  3. Pre-surgical illicit drug use

  4. Post-Surgical illicit drug use

Saules et al., 2010
  1. Medical record review

  2. Retrospective review of electronic medical records

  1. Review of 7,199 medical records

  2. Review of medical records of patients admitted to a drug and alcohol treatment program

  3. Admitted to drug and alcohol treatment program from April 16, 2006 to May 31, 2009 and have a history of WLS.

  4. N/A

  5. N/A

  6. N.D.

  7. Mean age =44.7(SD=9.2)

  8. 70.4% female

  9. 81.5% white

  1. N.D.

  2. Chart Review of substance abuse and alcohol abuse diagnoses among WLS patients

  1. Prevalence of patients admitted to a substance use treatment facility that have a history of WLS

  2. History of problematic alcohol use/alcohol use disorder

  3. Post-surgical problematic alcohol use/alcohol use disorder

Wiedemann et al., 2013
  1. Medical record review and semi-structured interview

  2. Retrospective review of electronic medical records, and interview one time after surgery with identified patients.

  1. Review of 4,658 medical records, and interview of 56 identified WLS patients.

  2. Review of medical records of patients admitted to a drug and alcohol treatment program, and recruitment to participate in an interview.

  3. Admitted to drug and alcohol treatment program from July 2009 to April 2011, have a history of WLS, and agreed to an interview.

  4. 91.07% (51 out of 56 patients)

  5. N/A

  6. 90.6% RYGB

  7. Mean age =44.8 (SD=7.11)

  8. 71.4% female

  9. 91.1% white,

  1. AUDIT-R for alcohol use, questions developed by investigators to assess illicit drug use/alcohol use trajectories (i.e. “Do you feel like your problems with alcohol/drugs began after you had bariatric surgery? If yes, please describe how you began or increased your use of alcohol/drugs, and how you become concerned that it might be a problem for you”), chart review, self-reported questionnaire, and semi-structured interview

  2. Self-reported questionnaire (N.D. if self-administered or interviewer administered) and interviewer administered semi-structured questionnaire.

  1. Prevalence of patients admitted to a substance use treatment facility that have a history of WLS

  2. History of problematic alcohol use/alcohol use disorder

  3. Post-surgical problematic alcohol use/alcohol use disorder

  4. Pre-surgical substance use disorder

  5. Post-surgical substance use disorder

Cuellar-Barboza et al., 2014
  1. Medical record review

  2. Retrospective review of electronic medical records

  • a. Review of 823 electronic medical records (EMR)

  • b. Data extracted from EMRs of patients treated at the Mayo Clinic Addiction Treatment Program, between June 2004 and July 2012

  • c. Patients aged 30-60 with a primary treatment diagnosis of AUD, and had the RYGB procedure

  • c. N/A

  • d. N/A

  • E. N/A

  • f. 100 %RYGB

  • g. Mean age of admission=46 (1.3)

  • h. 89.6% female

  • i. 92.7% white

  1. Clinical interview

  1. Prevalence of patients admitted to a substance use treatment facility that have a history of WLS

  2. History of problematic alcohol use/alcohol use disorder

  3. Post-surgical problematic alcohol use/alcohol use disorder

Ostlund et al., 2013
  1. Medical record review

  2. Review of all patients in Sweden who had bariatric surgery procedure from January 1, 1980 to December 31, 2006 via the Swedish Patient Registrar

  1. n= 11,115

  2. Review of the nationwide dataset, the Swedish Patient Registrar, from January 1, 1980 to December 31, 2006 for all patients who had bariatric surgery.

  3. Bariatric surgery patients

  4. Patients who had more than 1 bariatric procedure

  5. N/A

  6. 37% RYGB; 63% AGB & VBG

  7. RYGB cohort = 40.2 (10.1) AGB&VBG cohort =40.0 (10.4)

  8. RYGB cohort, female = 75%; AGB &VBG cohort, female =78%

  9. N.D. (study conducted in Sweden)

  1. Clinical diagnosis for substance abuse or alcohol abuse (no other information given)

  2. Chart Review of substance abuse and alcohol abuse diagnoses as documented in the Swedish Patient Register

  1. Prevalence of patients admitted to a substance use treatment facility that have a history of WLS

Omalu et al., 2007
  1. Retrospective record review

  2. Chart review of Pennsylvania State health care database and death records to examine death rate and causes of death for all Pennsylvania residents who had bariatric surgery from 1995-2005

  1. n=16,683 total surgeries; 440 deaths

  2. investigation of death rates and causes of death for all Pennsylvania residents who had bariatric surgery from 1995-2005

  3. N/A

  4. N/A

  5. N/A

  6. N.D.

  7. 48=Mean age at time of surgery

  8. 82.3% female (n=13,734)

  9. 81% white (n=13,504)

  1. Review of death records

  2. Chart review of death records obtained from the Division of Vital Records, Pennsylvania State Department of Health investigating drug overdose as cause of death

  1. Post-surgical illicit drug use

Reslan, Saules, Greenwald, & Schuh, 2014
  1. Cross-sectional; retrospective

  2. One time

  1. n=141

  2. Participants who previously participated in prior bariatric research or bariatric support groups were recruited.

  3. RYGB patients, at least 24 months post-operative; not currently pregnant

  4. N.D.

  5. N/A

  6. 100% RYGB

  7. mean age =53 (SD=10.33)

  8. 79% female (n=112)

  9. 93% white (=130)

  1. Michigan assessment-screening test for alcohol and drugs (MAST/AD) and the Alcohol, Smoking and Substance Involvement Screening Test(ASSIST)

  2. Self-reported; web-based survey or mailed survey

  1. Pre-surgical history of substance use disorders (alcohol and illicit drug use not distinguished).

  2. Post-surgical substance use disorders (alcohol and illicit drug use not distinguished).

Ivezaj, Saules, & Schuh, 2014
  1. Cross-sectional; retrospective

  2. One time

  1. n=143

  2. Participants recruited through St. Vincent Caramel Hospital's Bariatric Center of Excellence and through an online support group

  3. Post-surgical RYGB patients

  4. N.D.

  5. N/A

  6. 100% RYGB

  7. mean age= 48.97(SD=10.5)

  8. 83.9% female (n=120)

  9. 94.4% white (n=135)

  1. Michigan assessment-screening test for alcohol and drugs (MAST/AD)

  2. Self-reported; web-based survey

  1. Pre-surgical history of substance use disorders (alcohol and illicit drug use not distinguished).

  2. Post-surgical substance misuse (alcohol and illicit drug use not distinguished).

Fowler et al., 2014
  1. Cross-sectional; retrospective

  2. One time

  1. n=154

  2. N/A Secondary data analysis of a bariatric surgery patient database

  3. N/A

  4. N/A

  5. N/A

  6. 92.9% RYGB

  7. Mean age = 48.7 (SD=10.8)

  8. 88.4% female

  9. 94.2% white

  1. Michigan assessment-screening test for alcohol and drugs (MAST/AD) and Yale Food Addiction Scale (YFAS)

  2. N.D.

  1. Pre-surgical substance use disorders (alcohol and illicit drug use not distinguished) as related to pre-surgical endorsement of problematic intake of certain foods.

Fogger et al., 2012
  1. Cross-sectional

  2. One-time; post-surgery

  1. Total = 173; bariatric surgery patients =25

  2. Analysis of a sub-group of bariatric surgery patients among a study investigating the efficacy of a state-monitoring program for nurses with addictions i

  3. N/A

  4. 382 surveys mailed; 173 returned

  5. N/A

  6. N.D.

  7. N.D.

  8. Bariatric surgery subgroup: women=24

  9. N.D.

  1. Three qualitative questions regarding bariatric surgery: (1) Have you ever had bariatric surgery, (2) Did your problem with substances begin after surgery? (3) If you had a substance problem prior to surgery did it change after bariatric surgery?

  2. Mailed survey

  1. Prevalence of nurses who underwent bariatric surgery participating in a state monitoring program for nurses with addiction

Key: N.D. = no data; N/A= not applicable; RYGB = Roux en y gastric bypass; ASG = sleeve gastrectomy; AGB= Adjustable Gastric Band; VBG = vertical banded gastroplasty (stomach stapling); SD=standard deviation