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(a) Cα RMSD, (b) B-factors over final 500 ns, and (c) B-factor variance over 10 sequential independent trajectory segments of all investigated systems. All phosphorylated states exhibit elevated flexibility compared to the staurosporine-inhibited and the ATP-bound non-phosphorylated complexes. Regions of interest comprise the N-lobal residues 500–519 and the “flap-like” residues 537–569.
