Fig 4. Effect of PBTZ169, BTZ043, and SXT on the development of mycetoma lesions in BALB/c mice infected with N. brasiliensis HUJEG-1.

The Y axis is an arbitrary scale we developed to measure the degree of infection (14) and goes from the total absence of lesions (0.0 +) to the presence of abundant inflammation, abscesses and fistulae. Each dot represents the reading of one animal; all the groups were compared statistically against the saline control group by using the Variance test,. According to this analysis, significant differences were found for treatment with PBTZ169 (P = 0.017) but not BTZ043 (P = 0.667). The positive control group treated with SXT yielded a statistically significant value (P = 0.007).