Table 3. Ingenuity Pathway Analysis of Upstream Regulators in Erythrocytes of DBA Patients.
| -LOG10(p-value) 1 | activation z-score 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Upstream Regulators | D1 | D2 | D3 | D4 | D5 | D6 | D1 | D2 | D3 | D4 | D5 | D6 |
| MAPK1 | 2.9 | 5.0 | 3.5 | 4.1 | 1.5 | - | -2.4 | -2.6 | -2.4 | -2.2 | - | - |
| IFNG | 0.7 | 1.3 | 1.0 | - | - | - | 1.9 | 2.0 | 2.0 | - | - | - |
| EIF2AK2 | 3.1 | 5.2 | 3.5 | 3.3 | 1.6 | - | 2.0 | 1.4 | 2.0 | - | - | - |
| TNF | 1.4 | 2.4 | 1.4 | 2.2 | 2.5 | - | 0.8 | 0.8 | 1.2 | 0.9 | 0.3 | - |
| TP53 | 3.4 | 2.0 | 2.6 | 1.3 | - | - | -2.2 | -0.3 | 0.7 | - | - | - |
| CEBPA | - | 3.7 | 1.5 | 1.4 | 3.8 | - | - | -0.4 | - | - | 2.2 | - |
| MGEA5 | 3.6 | 1.7 | 2.7 | 3.5 | - | - | - | - | -1.6 | -0.4 | - | - |
| Lh | 7.3 | 3.4 | 2.2 | - | 1.9 | - | -2.0 | - | - | - | - | - |
| FSH | 6.1 | 2.8 | 1.7 | - | 1.5 | - | -2.0 | - | - | - | - | - |
| P38 MAPK | 1.9 | 1.7 | 1.5 | - | - | - | 1.2 | - | - | - | - | - |
1 p-values for significance of enrichment of regulator targets among the analyzed gene set.
2 Z-scores for prediction of the regulator activity based on their target expression change direction.