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. 2015 Oct 16;10(10):e0140795. doi: 10.1371/journal.pone.0140795

Fig 2. Ulipristal acetate (UPA) inhibits P4-dependent MDA-iPRA cell proliferation.

Fig 2

MDA-iPRA cultured on 96-well plates, were treated with vehicle or P4 (1 nM) and/or UPA (1 μM) in fresh steroid-free medium containing DMSO or RSL1 (0.5 μM) on day 0, 2 and 4. Cell proliferation assays were performed using CellTiter96H AqueousOne Solution as described in Materials and Methods. The 490 nm absorbance was determined on day 1, 3 and 5. Data are expressed as fold induction compared to vehicle condition arbitrarily set at 1, and are means ± SEM from five independent cell cultures (n = 6 for each experiment). ** indicates p<0.01 compared to the vehicle-treated cells for each MDA-iPRA cell line while xx indicates p<0.01 compared to the P4-treated cells (non-parametric Mann Whitney t-tests).