Table 4. Single-Nucleotide Polymorphisms in the HCV 5’-UTR Sequence from Plasma and PBMC Obtained at Two Collections Done More than 5 Years Apart from Patients after Spontaneous Resolution of Hepatitis C.
| Patient Age/Sex | HCV Genotype | Collection (Years of Follow-up) | Sample | Point Mutations | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| A120C | C126A | A134G | C203T | C209T | T212C | A223C | ||||
| 15-26/F | 3a | First (11) | Plasma | 7/7 | ND | 1/7 | 7/7 | ND | 1/7 | ND |
| PBMC | 10/10 | ND | ND | 10/10 | 1/10 | ND | 1/10 | |||
| Second (16.1) | Plasma | 10/10 | 1/10 | ND | 10/10 | 1/10 | ND | 1/10 | ||
| PBMC | 10/10 | ND | 1/10 | 10/10 | 1/10 | ND | ND | |||
| A96C | G110A | 127insC | C204T | G241A | G295C | |||||
| 20–49 | 1b | First (14.3) | Plasma | ND | 10/10 | 2/10 | 1/10 | ND | 10/10 | |
| Second (20.6) | Plasma | ND | 10/10 | 1/10 | ND | ND | 10/10 | |||
| PBMC | 1/10 | 10/10 | ND | ND | 1/10 | 10/10 | ||||
The results are presented as numbers of clones in which a given mutation was identified per total number of clones tested. The designation of the nucleotide position based on the prototype 3a and 1b subgenotype sequences D1773 and D11168, respectively, from GenBank. ND, not detected; NA, not available