Table 3. Relationship between clinico-pathological characteristics and hr- HPV Positivity.
| Characteristic | Total Cases (n = 106) N (%) | hr- HPV positive (n = 33) N (%) | hr-HPV Negative (n = 73) N (%) | Unadjusted OR [95%CI] | P –value |
|---|---|---|---|---|---|
| Univariate analysis | |||||
| Site | |||||
| Oral cavity † | 86 (81.13) | 24 (72.72) | 62 (84.93) | 4.73[0.17–1.28] | 1.40 |
| Laryngeal | 9 (8.49) | 2 (6.06) | 7 (9.58) | 0.61[0.11–3.10] | 0.55 |
| Hypopharyngeal | 3 (2.83) | 2 (6.06) | 1 (1.37) | 4.64[0.40–53.1] | 0.18 |
| Oropharyngeal | 5 (4.71) | 5 (15.15) | 0 (0.00) | - | <0.01* |
| Nose and PNS | 3 (2.83) | 0 (0.00) | 3 (4.10) | - | 0.24 |
| TNM Tumor stage | |||||
| II † | 15 (14.15) | 3 (9.09) | 12 (16.45) | 1.0 (referent) | |
| III | 26 (24.52) | 6 (18.18) | 20 (27.39) | 1.20 [0.20–7.55] | 1.00 |
| IVA | 59 (55.66) | 24 (72.73) | 35 (47.94) | 2.74[0.62–13.81] | 0.13 |
| IVB | 6 (5.66) | 0 (0.00) | 6 (8.21) | - | 0.52 |
| Histology | |||||
| Verrucous Carcinoma † | 8 (7.54) | 2 (6.06) | 6 (8.21) | 1.0 (referent) | |
| Squamous Cell Carcinoma | 91 (85.85) | 30 (90.91) | 61 (83.56) | 1.48[0.25–11.31] | 1.00 |
| Others | 7 (6.60) | 1 (3.03) | 6 (8.21) | 0.50[0.01–11.02] | 1.00 |
| Morphology | |||||
| Well Differentiated † | 74 (69.81) | 21 (63.63) | 53 (72.60) | 1.0 (referent) | |
| Moderate Differentiated | 22 (20.75) | 8 (24.24) | 14 (19.17) | 1.44[0.47–4.38] | 0.47 |
| Poor Differentiated | 10 (9.44) | 4 (12.12) | 6 (8.21) | 1.68[0.35–7.74] | 0.38 |
* Statistically Significant OR = odds ratio; CI = confidence interval;
† Reference group for OR calculation