Table 2. Results of QuantiFERON-TB Gold In-Tube and T-SPOT.TB tests in initial evaluation of LTBI in patients with rheumatic diseases scheduled for TNF-α antagonist therapy.
QFT-GIT | ||||
---|---|---|---|---|
T-SPOT.TB | Positive | Negative | Indeterminate a | Total |
Positive | 41 | 28 | 1 b | 70 |
Negative | 4 | 74 | 2 | 80 |
Indeterminate a | - | 6 | - | 6 |
Total | 45 | 108 | 3 | 156 |
LTBI, latent tuberculosis infection; TNF, tumor necrosis factor; QFT-GIT, QuantiFERON-TB Gold In-Tube.
aAll QFT-GIT indeterminate results occurred due to failure to generate an IFN-γ response to mitogens, and all T-SPOT.TB indeterminate results were due to excessive response of negative controls.
bOne QFT-GIT-indeterminate patient with a 10 mm tuberculin skin test result received TB medication.