Table 2.

Pooled means of sensitivity and specificity, diagnostic odds ratio (DOR), area under the curve (AUC) and calculated likelihood ratios for each tumor antigen

Antigen	Sensitivity (95% CI)	Specificity (95% CI)	DOR	AUC	PLR	NLR
CEA	0.549 (0.485 – 0.613)	0.962 (0.940 – 0.984)	30.8	0.81	14.45 (8.08 – 38.31)	0.47 (0.55 – 0.39)
CA15-3	0.507 (0.399 – 0.616)	0.983 (0.958 – 1.000)	59.5	0.78	29.82 (9.5 – *)	0.50 (0.63 – 0.38)
CA19-9	0.376 (0.077 – 0.675)	0.980 (0.948 – 1.000)	29.5	0.91	18.8 (1.48 – *)	0.64 (0.97 – 0.33)
CA125	0.575 (0.325 – 0.824)	0.928 (0.784 – 1.000)	17.4	0.79	7.99 (1.5 – *)	0.46 (0.86 – 0.18)
CYRA	0.625 (0.483 – 0.766)	0.932 (0.862 – 1.000)	22.8	0.84	9.19 (3.5 – *)	0.40 (0.6 – 0.23)
NSE	0.613 (0.264 – 0.963)	0.884 (0.730 – 1.000)	12.1	0.84	5.28 (0.98 – *)	0.44 (1.01 – 0.04)

^*Upper bound is undefined due to the upper bound of specificity equaling 1.0