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. 2015 Jul 10;8(2):92–99. doi: 10.1016/j.slsci.2015.06.002

Fig. 2.

Fig. 2

PPN cell types manifesting P/Q-type channels only, N-type channels only, or N- and P/Q-type channels. PPN cells with only P/Q-type calcium channels numbered 20%, and are assumed to be “Wake-on” and modulated by CaMKII. PPN cells with both N- and P/Q-type calcium channels numbered 50%, and are assumed to be Wake/REM-on” and modulated by both CaMKII and cAMP/PKA metabolic pathways. PPN cells with only N-type calcium channels numbered 30%, and are assumed to be “REM-on” and modulated by the cAMP/PKA pathway. P/Q-only and N+P/Q cells thus are expected to be active during waking, while N-only and N+P/Q cells are active during REM sleep.