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. 2015 Jul 19;38(11):1103–1113. doi: 10.1007/s40264-015-0327-3

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Time to first elevation of alanine aminotransferase to >3 × upper limit of normal in adjudicated subjects. a TEMPO 3:4: the apparent window of susceptibility is shown as shaded in yellow. All of the tolvaptan cases adjudicated as probable or higher are shown as green arrows and the two Hy’s Law cases are shown as red arrows. b TEMPO 4:4: the Hy’s Law case is shown as a red arrow. TLV tolvaptan