Table 1.
Arterial blood-gas analysis of pigs with occlusion and reperfusion of a coronary vessel treated with MRS 2179 (n = 8) or used as controls (n = 10)
Baseline |
1 min reperfusion |
5 min reperfusion |
||||
---|---|---|---|---|---|---|
Control | MRS2179 | Control | MRS2179 | Control | MRS2179 | |
PH | 7.48 ± 0.04 | 7.49 ± 0.04 | 7.46 ± 0.06 | 7.48 ± 0.04 | 7.46 ± 0.07 | 7.47 ± 0.03 |
pCO2 | 5.4 ± 0.7 | 5.3 ± 0.5 | 5.6 ± 0.9 | 5.3 ± 0.5 | 5.3 ± 0.6 | 5.3 ± 0.7 |
pO2 | 46.5 ± 17.1 | 44.5 ± 15.4 | 41.3 ± 13.4 | 44.3 ± 18.2 | 35.9 ± 3.6 | 36.2 ± 4.1 |
Na+ | 133 ± 2 | 135 ± 1 | 133 ± 1 | 134 ± 2 | 133 ± 2 | 135 ± 2 |
K+ | 3.5 ± 0.3 | 3.6 ± 0.3 | 3.5 ± 0.2 | 3.7 ± 0.3 | 3.5 ± 0.2 | 3.6 ± 0.1 |
Hb | 89 ± 7 | 91 ± 3 | 91 ± 6 | 92 ± 5 | 89 ± 4 | 92 ± 4 |
O2 | 97.1 ± 0.2 | 97.2 ± 0.2 | 97.6 ± 1.3 | 97.4 ± 0.4 | 97.3 ± 0.1 | 97.2 ± 0.2 |
HCO3 | 29.0 ± 1.7 | 30.0 ± 0.4 | 28.7 ± 1.4 | 29.6 ± 0.4 | 28.5 ± 1.2 | 29.3 ± 0.8 |
Base excess | 5.7 ± 0.7 | 6.1 ± 0.3 | 4.9 ± 0.9 | 5.5 ± 0.4 | 5.2 ± 0.6 | 5.4 ± 0.5 |
Samples were collected at baseline and at 1 and 5 min following reperfusion. There were no statistical differences between pigs treated with MRS 2179 or pigs used as controls. Data are expressed as mean ± SEM, p = NS