Fig. 4.

Effects of CSYJE on TNF-α and IFN-γ-stimulated productions of chemokines in HaCaT cells. Levels of TARC (a), MDC (b), RANTES (c), and IL-8 (d) were measured using the culture supernatants from cells treated with CSYJE (125, 250, or 500 μg/mL), and TNF-α and IFN-γ (each 10 ng/mL, TI) for 24 h. Silymarin (6.25, 12.5, or 25 μg/mL) was used as a positive control. Values were expressed as mean ± SEM of three independent experiments. ^## P < 0.01 vs vehicle control cells; and **P < 0.01 vs TI-treated cells